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SOCRA CCRP Exam Syllabus Topics:
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SOCRA Certified Clinical Research Professional (CCRP) Sample Questions (Q109-Q114):
NEW QUESTION # 109
Sponsor must maintain drug disposition records for how long after marketing approval?
- A. 1 year
- B. 5 years
- C. 3 years
- D. 2 years
Answer: D
Explanation:
* 21 CFR 312.57(c):"Sponsors shall retain records for2 years after a marketing application is approvedor if not approved, 2 years after shipment and delivery of investigational drug for investigation." References:21 CFR 312.57(c).
NEW QUESTION # 110
In accordance with the CFR, which of the following statements regarding the informed consent document is correct?
- A. It identifies all of the applicable mandated basic elements
- B. It does not identify some of the applicable mandated basic elements
- C. It is signed and dated by the subject's legally authorized representative
- D. It is signed and dated by the IRB/IEC chair
Answer: A
Explanation:
The informed consent document (ICD) is a cornerstone of ethical clinical research, ensuring voluntary participation and protection of subject rights.
* 21 CFR 50.25(a):Requires the consent form to containall basic elements, including study purpose, risks, benefits, alternatives, confidentiality, compensation, and voluntariness.
* ICH E6(R2) 4.8.10:Expands on these requirements, ensuring the ICD contains every mandated element without omission.
Thus, the correct statement is that the ICDmust include all applicable mandated basic elements(D).
Options A and B confuse who signs-subjects or legally authorized representatives sign when applicable, not the IRB chair. Option C is incorrect because leaving out elements would violate compliance.
Correct answer:D.
References:
21 CFR 50.25(a).
ICH E6(R2), §4.8.10.
NEW QUESTION # 111
During an IND study closeout, a monitor discovered remaining investigational product. Which procedures must be followed for disposition?
- A. Sponsor's procedures
- B. IRB/IEC's procedures
- C. Dispensing pharmacy's procedures
- D. Regulatory authority's procedures
Answer: A
Explanation:
* ICH E6(R2) 5.13.3:The sponsor is responsible for the supply, storage, and final disposition of investigational product.
* 21 CFR 312.59:Sponsors must assure return or proper disposition of unused supplies.
* Sites must followsponsor's written proceduresfor reconciliation, return, or destruction, not IRB or pharmacy processes.
References:ICH E6(R2) §5.13.3; 21 CFR 312.59.
NEW QUESTION # 112
A study coordinator is developing an informed consent form for the first time. As per the CFR and ICH GCP Guideline, which of the following elements must be included?
- A. A disclosure of appropriate alternative procedures or courses of treatment, if any, that might be advantageous to the subject
- B. An explanation of the person to contact at the sponsor for further information regarding research subjects' rights
- C. A statement confirming that the subject has received a copy of the signed consent document
- D. A note that the qualified investigator could be financially compensated by the sponsor to conduct the clinical trial
Answer: A
Explanation:
Theinformed consent processmust include all basic elements listed in federal regulations.
* 21 CFR 50.25(a)(4):Requires "a disclosure of appropriate alternative procedures or courses of treatment, if any, that might be advantageous to the subject."
* ICH E6(R2) 4.8.10(c):Mirrors this, requiring subjects to be informed of alternatives to participation, including available standard treatments.
This ensures the ethical principle ofRespect for Persons(Belmont Report), giving subjects the autonomy to choose among reasonable medical options.
Incorrect options:
* A: Contact information must be provided, but it is for the investigator (or IRB), not sponsor.
* B: Financial disclosures may be required for IRB review, not subject-facing.
* C: Subjects do receive a copy, but it is not a required consentelementin regulations.
Correct answer:D.
References:
21 CFR 50.25(a)(4).
ICH E6(R2), §4.8.10(c).
NEW QUESTION # 113
In an IND study, the specified dosage of an investigational product is 2 mg twice a day for 10 days. The product is available in 1 mg tablets. The subject was given 45 tablets and was instructed to take 2 mg of the product twice a day for 10 days. How many tablets should the subject have after the 10 days?
- A. 0
- B. 1
- C. 2
- D. 3
Answer: C
Explanation:
This question tests drug accountability and dosing calculation, which is central to ICH E6(R2) 4.6 (Investigational product management). Subjects must receive the correct supply and any discrepancy must be reconciled.
The prescribed regimen is 2 mg twice daily = 4 mg per day. With 1 mg tablets, this equals 4 tablets daily.
Over 10 days, the subject should consume 40 tablets (4 × 10 = 40). Since 45 tablets were dispensed, the subject should have 5 tablets remaining after 10 days.
Accurate accountability ensures trial integrity and subject safety. Investigators are responsible for maintaining investigational product (IP) records, including dispensing, usage, and returns. According to ICH:
4.6.3: "The investigator/institution should maintain records of the product's delivery to the trial site, the inventory, the use by each subject, and the return to the sponsor or alternative disposition."
4.6.5: "The investigator should ensure that investigational products are used only in accordance with the approved protocol." Thus, the correct answer is C (5 tablets remain). This reflects proper dosing compliance and highlights the importance of meticulous IP tracking in clinical trials.
References:
ICH E6(R2), §4.6 (Investigational Product(s)).
NEW QUESTION # 114
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